Evidence from research studies reports that wine consumption is associated with lower cardiovascular disease risk, partly through the amelioration of oxidative stress. The aim of the present study was to examine the effect of regular light to moderate wine consumption from coronary heart disease (CHD) patients compared to the effect induced by alcohol intake without the presence of wine microconstituents, on oxidation-induced macromolecular damage as well as on endogenous antioxidant enzyme activity.
A randomized, single-blind, controlled, three-arm parallel intervention was carried out, in which 64 CHD patients were allocated to three intervention groups. Group A consumed no alcohol, and Group B (wine) and Group C (ethanol) consumed 27 g of alcohol/day for 8 weeks. Blood and urine samples were collected at baseline and at 4 and 8 weeks. Urine oxidized guanine species levels, protein carbonyls, thiobarbituric acid substances (TBARS) levels, as well as superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, were measured.
Oxidized guanine species and protein carbonyl levels were significantly increased in the ethanol group during the intervention and were significantly decreased in the wine group. These results support the idea that wine’s bioactive compounds may exert antioxidant actions that counteract the macromolecular oxidative damage induced by alcohol in CHD patients.
Limitations of the study and significance:
This was a very small study conducted in Greece on patients with coronary heart disease. The amount of red wine used in the experiment is equivalent to approximately one large glass (200 ml). Despite the small scope of the study it does once again confirm that red wine contains anti-oxidants. In addition to the apple, a glass of red wine a day can keep the doctor away.
The abstract is reproduced in its original form as permitted by the open access policy of the journal Nutrients.
Choleva, M.; Argyrou, C.; Detopoulou, M.; Donta, M.-E.; Gerogianni, A.; Moustou, E.; Papaemmanouil, A.; Skitsa, C.; Kolovou, G.; Kalogeropoulos, P.; Fragopoulou, E. Effect of Moderate Wine Consumption on Oxidative Stress Markers in Coronary Heart Disease Patients. Nutrients 2022, 14, 1377. https://doi.org/10.3390/nu14071377
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